% Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Catalog Number 102331. No. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . CAS 9004-34-6, pH 5 - 7.5. Instead, they obtained a stable colloidal suspension. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Hi, let us know if you have any questions as you visit our website. gwf;J(e0o|1p{R~P^);ao!%{0KD7. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . %PDF-1.3 common form is used in vitamin supplements or tablets. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. };khd5x=fr MSDS Ref. Fiber supplements can lessen the absorption of some . FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . Microcrystalline Cellulose Side Effects. Looking for FMC'searnings news? The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Meet our leadership team. CAS #: 9004-34-6 . << Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Molecular Weight null. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. Watch Now. The cellulose molecule is formed through repeated condensation of cellobiose units. Gloves, eye protection and a dust mask should be used. An agricultural sciences company. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Material safety data sheet - FMC Corporation. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. These grades have particle sizes ranging from <30 to approximately 200. Watch Now. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. CoA. l~5C The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. : 5. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. 4 0 obj if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. MATERIAL SAFETY DATA SHEET Version: 1.0 1. <> Delivering efficient and robust formulations. Wu, K. Zuurman, H.W. gac74 [#B6`Wnw7 . Apply today! F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. The table below shows the most common physicochemical parameters of this raw material. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. stream The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. The short-term limit for total inhalable dust is 20 mg/m3. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. <> %PDF-1.4 A family of polysaccharide products that allow distinctive drug delivery solutions. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Safety Data Sheet for Cellulose microcrystalline 102331. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. We respect your privacy FMC Privacy Policy. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. No. Micro Crystalline Cellulose. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b The aqueous solution to barrier membrane coating. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. Go to Investor Relations. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. CAS 9004-34-6. ( 5 0 obj We can send by Fedex, by ship or by plane according to international rules. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. Heavy metals, % NMT 0.001 cas:9000-11-7 msds Carboxymethyl cellulose. In 1964 FMC, Corporation . It works as a moisture sponge and permits the controlled growth of spheroids. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Microcrystalline Cellulose / Avicel PH-102. Revision No. Avicel PC 611 Microcrystalline Cellulose. Molecular weight: Not Applicable 1.5. No. Battista, O. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. We are artists at heart and creators by nature. It is a white, free-flowing powder. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. 1 0 obj It is hygroscopic and insoluble in water. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. % Biologicals by FMC. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. /Parent 3 0 R % The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. The most. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . Doses up to 30 g per day appear to be . LOT #: Available upon request. Have an order or account question, find answers in our Online Support articles. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. Learn about FMC's differentiated biologically-based crop solutions. 4 0 obj It is also used in plaque assays for counting. The data shown below apply only to Avicel PH 101. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. q9;v80q>jZ << >> Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Cellulose microcrystalline. Production of Pharmaceutical Grade Microcrystalline Cellulose. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. These, in turn, are assembled into fibrils in the cell wall. INCI. CAS #: 9004-34-6 1.6. Performing this action will revert the following features to their default settings: Hooray! LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . w !1AQaq"2B #3Rbr Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . % FMC Corporation. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. undefined. P}MFbN#[>r(y <> It is available in different grades and particle sizes. BIOACCUMULATIVE POTENTIAL Avicel PH-200 microcrystalline cellulose NF, Ph. Revision No. Product Name: Microcrystalline Cellulose E460 1.2. EMCOCEL XLM 90. }o]X4]. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. Find answers in our support articles. Powder becomes slippery when wet. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Microcrystalline Cellulose / Avicel PH-102. It is . 2008-2023 ChemPoint. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. <> /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Are you looking for information about products and services by region? Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Explore how you can develop your career and bring your creative ideas to life at IFF. Avicel PC 611 (FMC Biopolymer) Supplied by. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. No. ( Created Date: 2/10/2020 8:51:41 PM . Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL <> The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. 1 0 obj Are you sure you want to delete your template? Validity Area. This Microcrystalline Cellulose . Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm . Superior Performance: Provides excellent water uptake and rapid swelling . In large quantities it provides dietary bulk and may lead to a laxative effect. Manufactured by: China . X\o^ %PDF-1.4 Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. (Microcrystalline Cellulose Market Pr. Manufacturer: FMC BioPolymer. 1.3. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . No. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world.