2022 Sep-Oct;40(5):586-590. doi: 10.1016/j.clindermatol.2022.01.002. NCI CPTC Antibody Characterization Program. 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. 8600 Rockville Pike 2022 Mar 15;10(3):624. doi: 10.3390/microorganisms10030624. Pityriasis means scaly, and rosea means pink, but the rashes may look red, gray, brown or purple. (2021) 85:4655. Keywords: adverse effect, coronavirus, cutaneous eruptions, immunization, pityriasis rosea, SARS-CoV-2, vaccine, case report, Citation: Leerunyakul K, Pakornphadungsit K and Suchonwanit P (2021) Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature. Accessibility 2022 Oct;49(10):948-956. doi: 10.1111/1346-8138.16482. We present two cases of COVID-19 vaccine-induced pityriasis rosea. You also wont have permanent scarring or other damage to your skin. Abdullah L, Hasbani D, Kurban M, Abbas O. Pityriasis rosea after mRNA COVID-19 vaccination. Pityriasis rosea often occurs this way, but not always. An official website of the United States government. Kroumpouzos G, Paroikaki ME, Yumeen S, Bhargava S, Mylonakis E. Microorganisms. Figure 1. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Few brownish patches also appeared, suggestive of post-inflammatory hyperpigmentation. Of the 30 cases found, none experienced severe adverse effects and the rash resolved in an average of 5.6 weeks. Pityriasis lichenoides is a clonal T-cell disorder that may develop in response to foreign antigens (eg, infections or drugs) and may be associated with cutaneous T-cell lymphoma. (a) Patient 1: Thin red to tan oval plaques with peripheral scale on the trunk. Martn Enguix D, Salazar Nievas MDC, Martn Romero DT. sharing sensitive information, make sure youre on a federal Is there a prescription cream or ointment that you can prescribe? Get many smaller patches or bumps on your skin. In my experience, patients with darker skin are more likely to present with atypical forms of the disorder. 78 PDF Pityriasis rosea following CoronaVac COVID19 vaccination: a case report Elin Akda, N. Ilter, B. t, . Erdem Under the treatment that was initiated a partial remission of the lesions after 7 days was observed. Would you like email updates of new search results? In approximately 50% of people with pityriasis rosea, the patches itch. Epub 2022 Feb 9. The site is secure. One case of pityriasis rosea is reported in a patient infected with COVID-19, and the most commonly reported features are exanthomatous rash, urticaria, chickenpox like vesicles, petechiae, and acute hemorrhagic edema of infancy. In a registry-based study, PR-like eruption was observed in only 12% of patients (14). These types cannot cause cold sores or genital herpes. The typical distribution of the rash is on the trunk between the neck and the knees.". Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk. HHS Vulnerability Disclosure, Help Your rash looks infected (red, purple, gray or white skin; irritation and swelling). -, Busto-Leis J.M., Servera-Negre G., Mayor-Ibarguren A., et al. Outcome: Leerunyakul K, Pakornphadungsit K, Suchonwanit P. Front Med (Lausanne). 2021;35(9):e546e548. They indicate that eight types of rash could be signs of Covid-19, including red toes and fingers, chest eczema and pityriasis rosea (scroll down for the full list). See this image and copyright information in PMC. National Library of Medicine Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. J Eur Acad Dermatol Venereol. Cutis. Human herpesvirus-6,7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19. Epub 2022 May 3. Dermatol Ther. They develop in a pattern that resembles sagging Christmas tree branches. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. Pityriasis rosea developing after COVID-19 vaccination. Careers. Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Int J Dermatol. Bathe or shower in lukewarm water. Parakeratosis with minimal acanthosis and spongiosis of the epidermis. doi: 10.1111/jdv.17316. Ramot Y, Nanova K, Faitatziadou SM, Assab DA, Berkun Y, Zlotogorski A. J Dtsch Dermatol Ges. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. doi: 10.1097/MD.0000000000029823. Suchonwanit P, Leerunyakul K, Kositkuljorn C. Diagnostic and prognostic values of cutaneous manifestations in COVID-19. Ehsani AH, Nasimi M, Bigdelo Z. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection. Accessibility J Eur Acad Dermatol Venereol. 94 PDF Pityriasis rosea and pityriasis rosea-like eruptions: How to distinguish them? Epub 2022 Jun 21. Theyre both papulosquoamous (pap-you-lo-skway-miss) disorders, which is a term used to characterize skin disorders according to the presence of raised, discolored, scaly patches of skin. The .gov means its official. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753512/), Visitation, mask requirements and COVID-19 information, sexually transmitted disease or infection. A virus may cause pityriasis rosea, but experts aren't sure. No use, distribution or reproduction is permitted which does not comply with these terms. Physical examination revealed that lesions were distributed along cleavage lines, similar to PR, without herald patch or prominent scales (Figure 1C). Federal government websites often end in .gov or .mil. (a) Pityriasis rosea (chest, flank, and axilla); (b) pityriasis rosea (back). and transmitted securely. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. 2021 Sep;35(9):e546-e548. 8600 Rockville Pike Here, we describe a case of PR-like eruption following ChAdOx1 nCoV-19 (AZD1222) vaccination in a Thai patient with glioblastoma. Would you like email updates of new search results? Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. official website and that any information you provide is encrypted Various mild and benign cutaneous manifestations of the different forms of the COVID-19 vaccine have been documented. Lasers Med Sci. Ad Choices. Vote for your favorite beauty products now! doi: 10.12998/wjcc.v5.i6.203, 6. Clipboard, Search History, and several other advanced features are temporarily unavailable. Before However, adverse effects to COVID-19 vaccines, particularly cutaneous reactions, have been reported. (a) haematoxylineosin, original magnification 10. Learning points: Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. Some treatments can alleviate related symptoms, including itching. Epub 2022 Jun 8. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. Blood tests to check for causes of a rash that arent related to pityriasis rosea. With COVID-19 vaccines being authorized for emergency use, monitoring for potential adverse effects (e.g., cutaneous reactions) is necessary. Please enable it to take advantage of the complete set of features! You may initially develop a fever, headache or upper respiratory infection. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. The authors have no conflicts of interest to declare. 7 Articles, This article is part of the Research Topic, Creative Commons Attribution License (CC BY), Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Suchonwanit P, Leerunyakul K, Kositkuljorn C. Cutaneous manifestations in COVID-19: Lessons learned from current evidence. Like previously reported cutaneous eruptions associated with COVID-19 infection, these cases "raise more questions than . 1. While it can spread all over the entire body, PR usually favors the trunk, says Christina Lam, an assistant professor of dermatology at Boston University School of Medicine and dermatologist at Boston Medical Center. Accessibility Clinical aspect of the lesions after 7 days of treatment. doi: 10.1002/ccr3.6096. doi: 10.1111/dth.15040, 3. Pityriasis Rosea Shortly After mRNA-1273 COVID-19 Vaccination. 2022 Oct 4;15:2117-2127. doi: 10.2147/CCID.S371630. government site. If you develop symptoms of pityriasis rosea while pregnant, contact your healthcare provider right away. Treatment with topical 0.1% triamcinolone acetonide twice per day showed partial response after seven days. Rybak-d'Obyrn J, Placek W, Owczarczyk-Saczonek A, Derkaczew M, Joniec E, Hofman R, Stompr M. Clin Cosmet Investig Dermatol. Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, et al. New York City-based dermatologist Macrene Alexiades. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. An official website of the United States government. 2022 Oct;123:58-69. doi: 10.1016/j.ijid.2022.06.037. . Moreover, central dusky-red erythematous was observed on some plaques (Figure 2A). Clipboard, Search History, and several other advanced features are temporarily unavailable. Some people see the rash disappear within 6 to 8 weeks, but it can take 5 months or longer for the skin to clear. J Formos Med Assoc. Cutis. 2021 May;62(2):e333-e334. An official website of the United States government. Nevertheless, the incidence of skin reactions after mRNA vaccinations was low. -, Broccolo F, Drago F, Careddu AM, et al. There isnt a cure, but it isnt contagious. Viruses, Variants, and Vaccines: How COVID-19 Has Changed the Way We Look at Skin. 2022 Jan;114:88-89. doi: 10.1016/j.ijid.2021.10.055. Treatment may include various topical and oral drugs. If you have pityriasis rosea, it can generally be well-managed without any treatment. The available COVID-19 vaccines entail different levels of risk for skin reactions. J Eur Acad Dermatol Venereol. Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). FOIA -. Our experience with 80 cases of SARS-CoV-2-Clostridioides difficile co-infection: An observational study. Int J Dermatol. COVID-19; Vaccination; pityriasis rosea. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. You cant spread pityriasis rosea to another person through unprotected sex or skin-to-skin contact. J Eur Acad Dermatol Venereol 2020; 34: e436-e437. The patient presented to the Department of Dermatology for a 3 week duration of an extremely pruritic erythematous-squamous lesion, initially on the trunk and upper limbs, with extension to the lower limbs in the last week and the lesion respected the cephalic extremity, palms, and soles. ", Though there's no single-known cause, King says, "pityriasis rosea is associated with reactivation of herpesviruses 6 and 7 [HHV-6 and HHV-7, respectively], which cause the primary rash, roseola, in infants. Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. Cutis. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. Adya KA, Inamadar AC, Albadri W. Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male. Pityriasis rosea doesnt usually affect people over the age of 60. Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. Epub 2021 Nov 2. If you have pityriasis rosea, its unlikely that youll get it again. J Eur Acad Dermatol Venereol. J Investig Dermatol 2005;124:123440. The papulovesicular and pityriasis rosea . Previously, PR has been reported in temporal association with various viral inoculations. Lawley LP, McCall CO, Lawley TJ. 2022 Aug;35(8):e15601. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report. Bethesda, MD 20894, Web Policies Dermatol Reports. Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. Epub 2021 May 10. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, Desai SR, French LE, Lim HW, Thiers BH, Hruza GJ, Blumenthal KG, Fox LP, Freeman EE. PMC We present the case of a female patient in whom the diagnosis of pityriasis rosea led to the investigation and diagnosis of the SARS-CoV-2 infection. Foods that have anti-inflammatory properties include: Foods that may increase inflammation include: There isnt any way to prevent pityriasis rosea. 8600 Rockville Pike Before Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report. Epub 2022 Jun 26. 2021 Aug;185(2):e34. -, Neoh CY, Tan AW, Mohamed K, et al. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. Epub 2021 Apr 26. Some treatments can alleviate related symptoms, including itching. Factors affecting the severity of central centrifugal cicatricial alopecia. Would you like email updates of new search results? 8 In some cases, antibodies against HHV6/7 as well as viral DNA in plasma and PBMCs were detected. Epub 2020 Jun 29. "It's usually not from head to toe that's more atypical but there are some people that get it more in the groin area or in the armpit rather than on the trunk predominantly, which is just a variant.". doi: 10.1111/bjd.20143. Do the medications have any side effects? Pityriasis Rosea Shortly After mRNA-1273 COVID-19 Vaccination. American Academy of Dermatology's National Library of Dermatologic Teaching Slides. The patient had a positive RT-PCR result, and was confirmed with SARS-CoV-2 infection. Br J Dermatol. This Month in JAAD International: August 2022: Cutaneous reactions to COVID-19 messenger RNA booster dose vaccination. Epub 2022 Jan 5. PMC Herald patch of pityriasis rosea. Br J Dermatol. Your California Privacy Rights. If you have pityriasis rosea, the rash with go away without treatment. The most commonly inoculated vaccines include those against smallpox, followed by tuberculosis, poliomyelitis, influenza, and human papillomavirus virus (12, 13). Advertising on our site helps support our mission. Keywords: Diagnoses: Australas J Dermatol. However, if it does, the symptoms may last for a longer period. Your symptoms dont improve after treatment. Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. Em Rata Just Debuted a Chic Italian Bob With Baby Bangs. A variant called inverse pityriasis rosea can affect the skin on your neck, face, armpits (axillae) and groin, though it isnt common. Your skin may develop discolored patches (lesions) that look like scales or dry, crinkly paper. An official website of the United States government. According to King, an in-person skin exam is usually enough to make an accurate diagnosis, though a biopsy or blood work may be necessary for some. headache.2 Several cutaneous adverse events after anti-COVID-19 vaccination are described in the literature, such as delayed large local reaction, urticaria, morbilliform eruptions, herpes zoster, "COVID arm," pityriasis rosea.3,4,5 Here, we report a case of a patient who presented with herpes zoster ophthalmicus (HZO) after the third dose Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. This site needs JavaScript to work properly. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. Other plausible theories include molecular mimicry with viral epitopes and type IV delayed hypersensitivity reaction (12). Those ensuing spots like the circle of dots that erupted on my back a day after the initial raised welt appeared typically resemble a Christmas tree-like formation. Another skin condition identified in the study were "vesicular eruptions" seen in 9 per cent of cases. Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk. Due to the rising incidence of coronavirus disease 2019 (COVID-19) worldwide, mass vaccination has been the cornerstone in preventing viral spread and decreasing morbidity and mortality. JAAD Int. Birlutiu V, Dobritoiu ES, Lupu CD, Herteliu C, Birlutiu RM, Dragomirescu D, Vorovenci A. COVID-19; SARS-CoV-2; pityriasis rosea; vaccination. Pityriasis Rosea as a Possible Complication of Vaccination Against COVID-19. Drago F, Ciccarese G, Rebora A, Parodi A. J Invest Dermatol. Marzano AV, Cassano N, Genovese G, Moltrasio C, Vena GA. Cutaneous manifestations in patients with COVID19: a preliminary review of an emerging issue. Histopathologic examination revealed epidermal focal spongiosis, interface dermatitis with necrotic keratinocytes, perivascular lymphocytic infiltration, and few eosinophilic infiltrations in the superficial dermis (Figures 3B,C). Careers. Dtsch Arztebl Int. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Some research shows that people who follow a Mediterranean diet have lower levels of inflammation in their bodies. Suchonwanit P, Triamchaisri S, Wittayakornrerk S, Rattanakaemakorn P. Leprosy Reaction in Thai Population: A 20-Year Retrospective Study. We present a case of a pityriasis rosea-like rash occurring after Pfizer COVID-19 vaccination and review cases of pityriasis rosea (PR)/PR-like eruption (PR-LE) after mRNA COVID-19 vaccine published in the medical literature. As King notes, there have been some reported cases of pityriasis rosea occurring in patients after receiving certain vaccines, like the flu shot. Histopathological findings of pityriasis rosealike eruption in patient 1. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature JAAD Int. Studies show that some skin conditions may appear with COVID-19, including pityriasis rosea. How long will it take my body to clear the rash? Bin Rubaian NF, Almuhaidib SR, Aljarri SA, Alamri AS. Now watch a pro surfer's entire daily routine: Follow Allure onInstagram andTwitter, orsubscribe to our newsletter to stay up to date on all things beauty. Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. This site needs JavaScript to work properly. Your healthcare provider can typically diagnose pityriasis rosea after a physical exam. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. -, Broccolo F., Drago F., Careddu A.M., et al. The https:// ensures that you are connecting to the These patches are smaller than the herald patch they range from 1 to 2 cm and are often called daughter patches. The .gov means its official. JAAD Case Rep. (2018) 4:8001. The study said the appearance was similar to pityriasis rosea, a common skin condition. and transmitted securely. Use of this site constitutes acceptance of our Federal government websites often end in .gov or .mil. Physicians should be aware that pityriasis rosea is a rare side-effect of COVID-19 vaccination.Pityriasis rosea is self-limiting and no medical treatment is usually required. Careers. Clinical findings of pityriasis rosealike, Clinical findings of pityriasis rosealike eruption in the patients. PR is a rare cutaneous reaction after mRNA vaccination against SARS-CoV-2. Bookshelf Disclaimer. Disclaimer. Bethesda, MD 20894, Web Policies Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Interventions: KL and KP collated resources. This reaction is self-limited and resolves in an average of 5.6 weeks. sharing sensitive information, make sure youre on a federal It could be pityriasis rosea here's how to treat it. Dermatol Online J. Refined carbohydrates, such as sugar, pastries and white bread. JAAD Int. A more recent letter in the International Journal of Dermatology reported a "unique case of pityriasis rosea following administration of mRNA COVID-19 vaccine." 2022 Nov 1;43(6):555-558. doi: 10.2500/aap.2022.43.220058. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. Herzum A, Trave I, D'Agostino F, Burlando M, Cozzani E, Parodi A. Clin Exp Vaccine Res. 2022 May;121(5):1003-1007. doi: 10.1016/j.jfma.2021.12.028. Br J Dermatol. The site is secure. ", The 29 Best Valentines Day Gifts for the Men in Your Life. eCollection 2022. The authors of one 2014 case report of a 71-year-old man who suffered from pityriasis rosea one month after receiving an influenza vaccine concluded that "altered immunity" could result in reactivation of HHV-6 and/or HHV-7 which may have triggered an atypical presentation of PR. See this image and copyright information in PMC. Europe PMC is an archive of life sciences journal literature. (2006) 12:1. doi: 10.5070/D380D8301D, 11. Additionally, differences in incidence of this reaction after Pfizer and Moderna vaccination may suggest a differing host immune response incited by these vaccines which warrants further investigation. -, Carballido Vzquez AM, Morgado B. Pityriasis rosea-like eruption after PfizerBioNTech COVID-19 vaccination. Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. Before Dermatol Ther. *Correspondence: Poonkiat Suchonwanit, poonkiat@hotmail.com, ORCID: Kanchana Leerunyakul orcid.org/0000-0002-0669-5611Kallapan Pakornphadungsit orcid.org/0000-0003-4783-0282Poonkiat Suchonwanit orcid.org/0000-0001-9723-0563, COVID-19 Associated Cutaneous Manifestations and COVID-19 Vaccine Related Skin Reactions, View all Accessibility World J Clin Cases. Moreover, while dermoscopy may facilitate the diagnosis of PR, its utility for atypical PR or PR-like lesions is still limited. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 Vaccine. . Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. The ones found in people with pityriasis rosea are human herpesviruses 6 and 7. Epub 2022 Jun 21. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same . Recurrent and persistent pityriasis rosea: an atypical case presentation.